Researchers at the Institute for Glycomics at the
Gold Coast Campus of Griffith University investigate the role of carbohydrates
in the progression of diseases such as cancer, tuberculosis, rotavirus
and skin disorders - in fact, almost every aspect of biology and many
infectious and pathological processes involve carbohydrates. Potentially,
this knowledge can be exploited to design potential new carbohydrate-base
entities to intervene in the biological processes that cause disease.
This requires a detailed knowledge of carohydrate structure and/or
protein function at a molecular level.
NMR spectroscopy is the method of choice for structural investigations
involving carbohydrates because, for complex carbhydrates (>10
sugar), the challenge of structural elucidation becomes intractable
if high-field NMR instruments are not available.